What is Restylane®?

Restylane is a safe and natural cosmetic dermal filler that restores volume and fullness to the skin to correct moderate to severe facial
wrinkles and folds, such as nasolabial folds.

What is Restylane made of?

Restylane is the fi rst cosmetic dermal filler made of non-animal-based hyaluronic acid. Hyaluronic acid is a natural substance that already exists in the human body and is used to provide volume and fullness to the skin. The hyaluronic acid in Restylane is a crystal-clear gel called NASHA,™ or Non- Animal Stabilized Hyaluronic Acid. NASHA is biodegradable and fully biocompatible with human hyaluronic acid.

How is Restylane different than other hyaluronic acid-based products?

Unlike rooster-derived hyaluronic acidbased products, Restylane is free from animal proteins. This quality limits any risk of animal-based disease transmission or allergic reaction. Restylane contains trace amounts of gram-positive bacterial proteins and should not be used by patients with a history of allergies to such material. Additionally,
Restylane has the highest concentration of hyaluronic acid available in a dermal filler.

Is Restylane® safe?

Yes. Restylane has been used by dermatologists and plastic surgeons since 1996 worldwide. There is limited risk of animalbased disease transmission or allergic reaction. Restylane is fully biocompatible and allergy testing is not required. Restylane contains trace amounts of gram-positive bacterial proteins and should not be used by patients with a history of allergies to such material. After your treatment, you might have some redness or swelling. This will normally
last less than seven days. Sunbathing and cold outdoor activities should be avoided until any redness or swelling disappear. If
you are pregnant, breastfeeding, or under 18, you shouldn’t use Restylane.

Can Restylane be used anywhere on the face?

Restylane has been used in more than 1.5 million treatments in over 60 countries to correct a variety of wrinkles. In the U.S. the
FDA has approved Restylane for wrinkles and folds like the ones from the nose to the corners of the mouth. Your doctor will consult with you prior to your injection regarding common treatment areas.

How long does Restylane last?

Restylane is proven to deliver long-lasting results. Studies have shown that Restylane effects generally last for about six months1. Restylane’s stabilization technology helps maintain the cosmetic effect until the injected material is nearly gone.

How often should I have Restylane® treatments done?

Treatments are typically scheduled twice a year. Having a touch-up treatment before the product has fully dissipated may enhance the
lasting effect.

What should patients do prior to treatment?

Restylane requires no pretesting, but you should take a few precautions before being treated. Avoid using aspirin, non-steroidal
anti-infl ammatory medications, St. John’s Wort, or high doses of Vitamin E supplements prior to treatment, because these may
increase bruising or bleeding at the injection site. Also, if you have previously suffered from facial cold sores, discuss this with your
physician. He/She may consider prescribing a medication to minimize recurrence.

How is Restylane different from Botox® Cosmetic?

Restylane is a natural, cosmetic fi ller. In contrast, Botox Cosmetic is a drug that blocks nerve transmission and relaxes the underlying muscles. Many patients have been very pleased after receiving treatment with both products.

How is Restylane different from bovine collagen?

Bovine collagen is derived from animals (cows) and requires an allergy test. Restylane can be administered immediately—no waiting is required.

Do the injections hurt?

Restylane® is injected directly into the skin in tiny amounts by an ultrafi ne needle, resulting in minimal discomfort. The procedure
is simple and convenient, and results are practically instantaneous. To optimize your comfort during the short procedure, your physician may anesthetize the treatment area.

How much do Restylane treatments cost?

Restylane is a customized procedure based on your specifi c needs, so the cost will vary from patient to patient. In general, the cost
of Restylane is comparable to the cost of similar procedures. Because Restylane is long lasting,1 it proves to be very economical over
the long term. Please consult your physician to determine the best recommendation for your particular needs.

Who is Medicis Aesthetics™?

Medicis Aesthetics is a subsidiary of Medicis,® a well-established dermatology company dedicated to helping patients attain a healthy
and youthful appearance and self-image.

Safety informatioSafety information

After your treatment, you might have some redness or swelling. This will normally last less than seven days. Sunbathing and cold outdoor
activities should be avoided until any redness or swelling disappear. If you are pregnant, breastfeeding, or under 18, you shouldn’t
use Restylane. For complete product and safety information, visit www.RestylaneUSA.com

Why wait?

If you want to enjoy a smoother, more youthful appearance for about six months,1 ask your physician if Restylane® is right for you.

• Restylane is a safe, natural formulation
• A simple convenient procedure
• Over 1.5 million treatments worldwide

Register now!
Go to www.RestylaneUSA.com to fi nd out how you can join Restylane Rewards™ and earn gifts for being a loyal customer. After each
treatment, you’ll be rewarded with your choice of gift cards from Barnes & Noble or Nordstrom, or a prepaid Restylane Visa Gift cardRestylane card.2

Don’t miss out!